| 1000043010 | eonsight | FR-France | Company | No | Alumnus | ESA BIC Nord France | |
| 1000049639 | Eos Space Technology | GB-United Kingdom | Company | Yes | Incubatee | ESA BIC UK | |
| 1000035070 | Ephemersys LLC | HU-Hungary | Company | Yes | Alumnus | ESA BIC Hungary | |
| 1000047739 | Epona AI Labs Limited | IE-Ireland | Company | Yes | Incubatee | ESA BIC Ireland | |
| 1000029559 | Eptune Engineering Lda. | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000049752 | EquaFish AS | NO-Norway | Company | Yes | Incubatee | ESA BIC Norway | |
| 1000047278 | Erend Space P.S.A. | PL-Poland | Company | No | Alumnus | ESA BIC Poland | |
| 1000050087 | ERLEtek | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000046223 | Esferatros UG | DE-Germany | Company | No | Alumnus | ESA BIC North Rhine-Westphalia | |
| 1000042695 | ESG Solutions & Consulting GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000035077 | Estimo-GNSS | EE-Estonia | Company | No | Alumnus | ESA BIC Estonia | |
| 1000039473 | EULA IT GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000041873 | Evolunar S.R.L. | IT-Italy | Company | No | Alumnus | ESA BIC Turin | |
| 1000049807 | EWIA.tech Unternehmergesellschaft (haftungsbeschraenkt) | DE-Germany | Company | No | Incubatee | ESA BIC Hessen | |
| 1000044791 | excav UG (haftungsbeschraenkt) | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000042561 | Excellion GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000036054 | Exobotics Ltd | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000048834 | ExoGen Space s.r.o. | CZ-Czech Republic | Company | Yes | Incubatee | ESA BIC Czech Republic | |
| 1000043812 | ExoMatter GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000048372 | ExoSat | FR-France | Company | Yes | Alumnus | ESA BIC Nord France | |