| 1000046188 | UniteLabs GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000043683 | UNIVITY | FR-France | Company | Yes | Alumnus | ESA BIC Nord France | |
| 1000041513 | Unleash Future Boats | DE-Germany | Company | No | Alumnus | ESA BIC Northern Germany | |
| 1000043438 | Unmanned Dynamics UAB | LT-Lithuania | Company | No | Alumnus | ESA BIC Lithuania | |
| 1000037693 | Unmanned Technical Works S.L.L. | ES-Spain | Company | No | Alumnus | ESA BIC Madrid Region | |
| 1000039044 | UNSEENLABS | FR-France | Company | Yes | Alumnus | ESA BIC Nord France | |
| 1000041825 | UP Catalyst OÜ | EE-Estonia | Company | Yes | Alumnus | ESA BIC Estonia | |
| 1000036916 | Upteko | DK-Denmark | Company | No | Alumnus | ESA BIC Denmark | |
| 1000029690 | Uptimai s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000031590 | UptoEarth | DE-Germany | Company | Yes | Alumnus | ESA BIC Hessen | |
| 1000039821 | Urban Ray GmbH | DE-Germany | Company | No | Alumnus | ESA BIC North Rhine-Westphalia | |
| 1000039475 | UrbanDataLab AG | CH-Switzerland | Company | No | Alumnus | ESA BIC Switzerland | |
| 1000043665 | UrbanSens UG (Haftungsbeschränkt) | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000027910 | UrbyetOrbit srls | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000030271 | uSEA AS | NO-Norway | Company | No | Alumnus | ESA BIC Norway | |
| 1000040599 | Uvireso, UAB | LT-Lithuania | Company | Yes | Alumnus | ESA BIC Lithuania | |
| 1000047596 | Vabelmat Technologies FlexKapG | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000028608 | vaireco GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Baden-Württemberg | |
| 1000033021 | Vake AS | NO-Norway | Company | Yes | Alumnus | ESA BIC Norway | |
| 1000039759 | Valar Space S.L. | ES-Spain | Company | Yes | Alumnus | ESA BIC Madrid Region | |