| 1000044902 | Zyglox OG | AT-Austria | Company | No | Incubatee | ESA BIC Austria | |
| 1000042408 | zeroCO2 | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000034427 | Zero Gravity Oy | FI-Finland | Company | Yes | Alumnus | ESA BIC Finland | |
| 1000033809 | Zaitra s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000031615 | yuri GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Baden Württemberg | |
| 1000040606 | Yuman ApS | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000045240 | YPLASMA ACTUATORS TECHNOLOGIES, S.L | ES-Spain | Company | Yes | Incubatee | ESA BIC Barcelona | |
| 1000045420 | YLISENSE Private Company | GR-Greece | Company | No | Incubatee | ESA BIC Greece | |
| 1000028820 | YETITMOVES | IT-Italy | Company | Yes | Alumnus | ESA BIC Lazio | |
| 1000042696 | YEET Aerospace LTD | GB-United Kingdom | Company | No | Incubatee | ESA BIC UK | |
| 1000036735 | XRnanotech GmbH | CH-Switzerland | Company | Yes | Alumnus | ESA BIC Switzerland | |
| 1000047690 | XR Space | PL-Poland | Company | Yes | Incubatee | ESA BIC Poland | |
| 1000042340 | Xiroi Aerospace S.L. | ES-Spain | Company | No | Incubatee | ESA BIC Barcelona | |
| 1000042375 | xFlight GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000041644 | Xeno Patch UG (Haftungsbeschränkt) | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000026661 | WxFUSION | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000028287 | World from Space | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000043834 | Wondrous Globe Unipessoal Lda | PT-Portugal | Company | Yes | Incubatee | ESA BIC Portugal | |
| 1000026933 | Wise Robotics Srls | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000044816 | Winse Power Oy | FI-Finland | Company | No | Alumnus | ESA BIC Finland | |