| 1000035182 | Eyecon - Software, Lda. | PT-Portugal | Company | Yes | Alumnus | ESA BIC Portugal | |
| 1000041665 | Eye4Sky Technologies S.L. | ES-Spain | Company | Yes | Incubatee | ESA BIC Madrid Region | |
| 1000042829 | Extremo Technologies | PL-Poland | Company | Yes | Alumnus | ESA BIC Poland | |
| 1000037481 | Extend Robotics | GB-United Kingdom | Company | No | Alumnus | ESA BIC UK | |
| 1000043812 | ExoMatter GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000036054 | Exobotics Ltd | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000042561 | Excellion GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000044791 | excav UG (haftungsbeschraenkt) | DE-Germany | Company | No | Incubatee | ESA BIC Bavaria | |
| 1000041873 | Evolunar S.R.L. | IT-Italy | Company | Yes | Alumnus | ESA BIC Turin | |
| 1000039473 | EULA IT GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000035077 | Estimo-GNSS | EE-Estonia | Company | No | Alumnus | ESA BIC Estonia | |
| 1000042695 | ESG Solutions & Consulting GmbH | AT-Austria | Company | Yes | Incubatee | ESA BIC Austria | |
| 1000046223 | Esferatros UG | DE-Germany | Company | No | Incubatee | ESA BIC North Rhine-Westphalia | |
| 1000047278 | Erend Space P.S.A. | PL-Poland | Company | No | Incubatee | ESA BIC Poland | |
| 1000029559 | Eptune Engineering Lda. | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000035070 | Ephemersys LLC | HU-Hungary | Company | Yes | Alumnus | ESA BIC Hungary | |
| 1000036736 | EOLAS Insight Ltd | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000028618 | Enlightra SARL | CH-Switzerland | Company | Yes | Alumnus | ESA BIC Switzerland | |
| 1000030984 | Engineering Minds Munich GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000038978 | Enernite AS | NO-Norway | Company | Yes | Alumnus | ESA BIC Norway | |