| 1000039812 | StepUp Horse ApS | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000042724 | StellarShip Labs UG (haftungsbeschränkt) | DE-Germany | Company | Yes | Incubatee | ESA BIC Bavaria | |
| 1000047897 | Stellar Discoveries P. C. | GR-Greece | Company | Yes | Alumnus | ESA BIC Greece | |
| 1000043321 | Starflight Dynamics GmbH | DE-Germany | Company | Yes | Incubatee | ESA BIC Bavaria | |
| 1000028911 | STAP GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000045249 | SRD Electronics UG (haftungsbeschränkt) | DE-Germany | Company | No | Incubatee | ESA BIC Hessen | |
| 1000043863 | Sports Impact Technologies Limited | IE-Ireland | Company | No | Incubatee | ESA BIC Ireland | |
| 1000042170 | Spiromagic ApS | DK-Denmark | Company | No | Alumnus | ESA BIC Denmark | |
| 1000034295 | SPIDERLOG SRL | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000040339 | Spherical Systems B.V. | NL-Netherlands | Company | Yes | Alumnus | ESA BIC Noordwijk | |
| 1000034221 | Spectarfold Ltd. | HU-Hungary | Company | No | Alumnus | ESA BIC Hungary | |
| 1000028166 | SpazioFuturo Srl | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000045723 | Spatialis | LT-Lithuania | Company | No | Incubatee | ESA BIC Lithuania | |
| 1000041177 | SPASCAT Technologies S.L. | ES-Spain | Company | Yes | Incubatee | ESA BIC Barcelona | |
| 1000036658 | Spartan Space | FR-France | Company | Yes | Alumnus | ESA BIC Sud France | |
| 1000042374 | Spark SRL | IT-Italy | Company | Yes | Incubatee | ESA BIC Lazio | |
| 1000044674 | SPAICE Technology S.r.l. | IT-Italy | Company | Yes | Incubatee | ESA BIC Turin | |
| 1000034200 | SpaceWay, Lda | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000037197 | Spacetek Technology AG | CH-Switzerland | Company | Yes | Alumnus | ESA BIC Switzerland | |
| 1000035372 | Spacept | SE-Sweden | Company | No | Alumnus | ESA BIC Sweden | |