| 1000040903 | SpaceMotionery s.r.l. | IT-Italy | Company | No | Alumnus | ESA BIC Turin | |
| 1000034843 | SpacEngineer Lda | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000035372 | Spacept | SE-Sweden | Company | No | Alumnus | ESA BIC Sweden | |
| 1000034200 | SpaceWay, Lda | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000045723 | Spatialis | LT-Lithuania | Company | No | Incubatee | ESA BIC Lithuania | |
| 1000028166 | SpazioFuturo Srl | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000034221 | Spectarfold Ltd. | HU-Hungary | Company | No | Alumnus | ESA BIC Hungary | |
| 1000034295 | SPIDERLOG SRL | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000042170 | Spiromagic ApS | DK-Denmark | Company | No | Alumnus | ESA BIC Denmark | |
| 1000043863 | Sports Impact Technologies Limited | IE-Ireland | Company | No | Incubatee | ESA BIC Ireland | |
| 1000045249 | SRD Electronics UG (haftungsbeschränkt) | DE-Germany | Company | No | Incubatee | ESA BIC Hessen | |
| 1000026904 | STRA, S.A. | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000038040 | STRADOT S.A.S. | FR-France | Company | No | Alumnus | ESA BIC Sud France | |
| 1000031500 | Strain 2 Data bvba | BE-Belgium | Company | No | Alumnus | ESA BIC Belgium | |
| 1000041505 | STRONGBÓ AGRITECH LIMITED | IE-Ireland | Company | No | Alumnus | ESA BIC Ireland | |
| 1000026720 | Studiomapp srl | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000032462 | Styx Neutronica GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Baden-Württemberg | |
| 1000042128 | SunCubes Srl | IT-Italy | Company | No | Alumnus | ESA BIC Turin | |
| 1000040613 | SunPlower Propeller GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000041474 | SUNWELL | CH-Switzerland | Company | No | Alumnus | ESA BIC Switzerland | |