| 1000034843 | SpacEngineer Lda | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000042818 | Spaceping Technologies GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Hessen | |
| 1000035372 | Spacept | SE-Sweden | Company | No | Alumnus | ESA BIC Sweden | |
| 1000033153 | SpaceSense | FR-France | Company | No | Alumnus | ESA BIC Nord France | |
| 1000034200 | SpaceWay, Lda | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000047123 | Spark Towers France | FR-France | Company | No | Alumnus | ESA BIC Sud France | |
| 1000041177 | SPASCAT Technologies S.L. | ES-Spain | Company | No | Alumnus | ESA BIC Barcelona | |
| 1000028166 | SpazioFuturo Srl | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000034221 | Spectarfold Ltd. | HU-Hungary | Company | No | Alumnus | ESA BIC Hungary | |
| 1000047013 | Spectrum Blue AS | NO-Norway | Company | No | Alumnus | ESA BIC Norway | |
| 1000034295 | SPIDERLOG SRL | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000042170 | Spiromagic ApS | DK-Denmark | Company | No | Alumnus | ESA BIC Denmark | |
| 1000043863 | Sports Impact Technologies Limited | IE-Ireland | Company | No | Alumnus | ESA BIC Ireland | |
| 1000047949 | starview srl | IT-Italy | Company | No | Incubatee | ESA BIC Turin | |
| 1000050552 | Stellar Alpina AG | CH-Switzerland | Company | No | Incubatee | ESA BIC Switzerland | |
| 1000039812 | StepUp Horse ApS | DK-Denmark | Company | No | Alumnus | ESA BIC Denmark | |
| 1000039268 | Stirweld | FR-France | Company | No | Alumnus | ESA BIC Nord France | |
| 1000026904 | STRA, S.A. | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000038040 | STRADOT S.A.S. | FR-France | Company | No | Alumnus | ESA BIC Sud France | |
| 1000031500 | Strain 2 Data bvba | BE-Belgium | Company | No | Alumnus | ESA BIC Belgium | |