| 1000049941 | empiriQa | PL-Poland | Company | Yes | Incubatee | ESA BIC Poland | |
| 1000038978 | Enernite AS | NO-Norway | Company | Yes | Alumnus | ESA BIC Norway | |
| 1000030984 | Engineering Minds Munich GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000037711 | Enovus Labs Ltd | IE-Ireland | Company | Yes | Incubatee | ESA BIC Ireland | |
| 1000046225 | Envira | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000036736 | EOLAS Insight Ltd | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000049639 | Eos Space Technology | GB-United Kingdom | Company | Yes | Incubatee | ESA BIC UK | |
| 1000035070 | Ephemersys LLC | HU-Hungary | Company | Yes | Alumnus | ESA BIC Hungary | |
| 1000047739 | Epona AI Labs Limited | IE-Ireland | Company | Yes | Incubatee | ESA BIC Ireland | |
| 1000049752 | EquaFish AS | NO-Norway | Company | Yes | Incubatee | ESA BIC Norway | |
| 1000050087 | ERLEtek | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000042695 | ESG Solutions & Consulting GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000042561 | Excellion GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000036054 | Exobotics Ltd | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000048834 | ExoGen Space s.r.o. | CZ-Czech Republic | Company | Yes | Incubatee | ESA BIC Czech Republic | |
| 1000043812 | ExoMatter GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000048372 | ExoSat | FR-France | Company | Yes | Alumnus | ESA BIC Nord France | |
| 1000052532 | EXOVIRO sp. z o.o. (Ltd.) | PL-Poland | Company | Yes | Incubatee | ESA BIC Poland | |
| 1000042829 | Extremo Technologies | PL-Poland | Company | Yes | Alumnus | ESA BIC Poland | |
| 1000035182 | Eyecon - Software, Lda. | PT-Portugal | Company | Yes | Alumnus | ESA BIC Portugal | |