| 1000042818 | Spaceping Technologies GmbH | DE-Germany | Company | Yes | Incubatee | ESA BIC Hessen | |
| 1000037197 | Spacetek Technology AG | CH-Switzerland | Company | Yes | Alumnus | ESA BIC Switzerland | |
| 1000044674 | SPAICE Technology S.r.l. | IT-Italy | Company | Yes | Incubatee | ESA BIC Turin | |
| 1000042374 | Spark SRL | IT-Italy | Company | Yes | Incubatee | ESA BIC Lazio | |
| 1000036658 | Spartan Space | FR-France | Company | Yes | Alumnus | ESA BIC Sud France | |
| 1000041177 | SPASCAT Technologies S.L. | ES-Spain | Company | Yes | Incubatee | ESA BIC Barcelona | |
| 1000040339 | Spherical Systems B.V. | NL-Netherlands | Company | Yes | Alumnus | ESA BIC Noordwijk | |
| 1000028911 | STAP GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000043321 | Starflight Dynamics GmbH | DE-Germany | Company | Yes | Incubatee | ESA BIC Bavaria | |
| 1000047897 | Stellar Discoveries P. C. | GR-Greece | Company | Yes | Alumnus | ESA BIC Greece | |
| 1000042724 | StellarShip Labs UG (haftungsbeschränkt) | DE-Germany | Company | Yes | Incubatee | ESA BIC Bavaria | |
| 1000039812 | StepUp Horse ApS | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000033433 | Sternula A/S | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000033385 | Stratobotic s.r.l. | IT-Italy | Company | Yes | Alumnus | ESA BIC Turin | |
| 1000033762 | STRATOSYST s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000039852 | SUNNYB Innovations GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000037618 | super-sharp Space Systems Limited | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000026758 | Survey Lab | IT-Italy | Company | Yes | Alumnus | ESA BIC Lazio | |
| 1000033592 | Swarm Logistics GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Baden Württemberg | |
| 1000040450 | Synchropal srl | IT-Italy | Company | Yes | Alumnus | ESA BIC Turin | |