| 1000047463 | Space-Lock RD GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000040798 | SpaceLocker | FR-France | Company | Yes | Alumnus | ESA BIC Nord France | |
| 1000032089 | Spacemanic CZ s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000026584 | Spacenus GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Hessen | |
| 1000042701 | Spaceo Lda. | PT-Portugal | Company | Yes | Alumnus | ESA BIC Portugal | |
| 1000040783 | SPACERACE s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000037197 | Spacetek Technology AG | CH-Switzerland | Company | Yes | Alumnus | ESA BIC Switzerland | |
| 1000044674 | SPAICE Technology S.r.l. | IT-Italy | Company | Yes | Alumnus | ESA BIC Turin | |
| 1000042374 | Spark SRL | IT-Italy | Company | Yes | Alumnus | ESA BIC Lazio | |
| 1000045723 | Spatialis | LT-Lithuania | Company | Yes | Alumnus | ESA BIC Lithuania | |
| 1000045249 | SRD Electronics UG (haftungsbeschränkt) | DE-Germany | Company | Yes | Alumnus | ESA BIC Hessen | |
| 1000028911 | STAP GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000043321 | Starflight Dynamics GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000046368 | StarGrip Hungary Kft. | HU-Hungary | Company | Yes | Alumnus | ESA BIC Hungary | |
| 1000047897 | Stellar Discoveries P. C. | GR-Greece | Company | Yes | Incubatee | ESA BIC Greece | |
| 1000045838 | Stellar Nuclear s.r.o. | CZ-Czech Republic | Company | Yes | Incubatee | ESA BIC Czech Republic | |
| 1000048695 | STELLAR PHRONESIS TECHNOLOGY P.C. | GR-Greece | Company | Yes | Incubatee | ESA BIC Greece | |
| 1000042724 | StellarShip Labs GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000033433 | Sternula A/S | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000033385 | Stratobotic s.r.l. | IT-Italy | Company | Yes | Alumnus | ESA BIC Turin | |