| 1000046360 | EMBEREYE LTD | GB-United Kingdom | Company | No | Incubatee | ESA BIC UK | |
| 1000021377 | EMBOTECH AG | CH-Switzerland | Company | No | Alumnus | ESA BIC Switzerland | |
| 1000050817 | Emissium SA | CH-Switzerland | Company | No | Incubatee | ESA BIC Switzerland | |
| 1000023388 | EMTECH GMBH | DE-Germany | Company | No | Alumnus | ESA BIC Hessen | |
| 1000041182 | ENANTIOS | CH-Switzerland | Company | No | Alumnus | ESA BIC Switzerland | |
| 1000046582 | encosa energy GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000026982 | Energeo Ltd | GB-United Kingdom | Company | No | Alumnus | ESA BIC UK | |
| 1000043147 | energyfamily GmbH | AT-Austria | Company | No | Alumnus | ESA BIC Austria | |
| 1000028618 | Enlightra SARL | CH-Switzerland | Company | No | Alumnus | ESA BIC Switzerland | |
| 1000035144 | Entrant s.r.o. | CZ-Czech Republic | Company | No | Alumnus | ESA BIC Czech Republic | |
| 1000050145 | Enwave P.S.A. | PL-Poland | Company | No | Incubatee | ESA BIC Poland | |
| 1000043010 | eonsight | FR-France | Company | No | Alumnus | ESA BIC Nord France | |
| 1000029559 | Eptune Engineering Lda. | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000047278 | Erend Space P.S.A. | PL-Poland | Company | No | Alumnus | ESA BIC Poland | |
| 1000046223 | Esferatros UG | DE-Germany | Company | No | Alumnus | ESA BIC North Rhine-Westphalia | |
| 1000035077 | Estimo-GNSS | EE-Estonia | Company | No | Alumnus | ESA BIC Estonia | |
| 1000039473 | EULA IT GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000041873 | Evolunar S.R.L. | IT-Italy | Company | No | Alumnus | ESA BIC Turin | |
| 1000049807 | EWIA.tech Unternehmergesellschaft (haftungsbeschraenkt) | DE-Germany | Company | No | Incubatee | ESA BIC Hessen | |
| 1000044791 | excav UG (haftungsbeschraenkt) | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |