| 1000040646 | ubicube GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000037958 | Uneeqly s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000024199 | UNIBAP AB | SE-Sweden | Company | Yes | Alumnus | ESA BIC Sweden | |
| 1000046188 | UniteLabs GmbH | DE-Germany | Company | Yes | Incubatee | ESA BIC Bavaria | |
| 1000043438 | Unmanned Dynamics UAB | LT-Lithuania | Company | Yes | Incubatee | ESA BIC Lithuania | |
| 1000041825 | UP Catalyst OÜ | EE-Estonia | Company | Yes | Alumnus | ESA BIC Estonia | |
| 1000036916 | Upteko | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000029690 | Uptimai s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000031590 | UptoEarth | DE-Germany | Company | Yes | Alumnus | ESA BIC Hessen | |
| 1000039821 | Urban Ray GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC North Rhine-Westphalia | |
| 1000043665 | UrbanSens UG (Haftungsbeschränkt) | DE-Germany | Company | Yes | Alumnus | ESA BIC Bavaria | |
| 1000030653 | U-Space | FR-France | Company | Yes | Alumnus | ESA BIC Sud France | |
| 1000040599 | Uvireso, UAB | LT-Lithuania | Company | Yes | Incubatee | ESA BIC Lithuania | |
| 1000047596 | Vabelmat Technologies FlexKapG | AT-Austria | Company | Yes | Incubatee | ESA BIC Austria | |
| 1000033021 | Vake AS | NO-Norway | Company | Yes | Alumnus | ESA BIC Norway | |
| 1000039759 | Valar Space S.L. | ES-Spain | Company | Yes | Alumnus | ESA BIC Madrid Region | |
| 1000033718 | Varadis | IE-Ireland | Company | Yes | Alumnus | ESA BIC Ireland | |
| 1000044667 | Ventus Technologies GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Baden-Württemberg | |
| 1000031988 | VEOWARE SPRL | BE-Belgium | Company | Yes | Alumnus | ESA BIC Belgium | |
| 1000046575 | Versatile Robotics GmbH | DE-Germany | Company | Yes | Incubatee | ESA BIC Bavaria | |