| 1000038150 | smartHAPS S.L. | ES-Spain | Company | No | Alumnus | ESA BIC Madrid Region | |
| 1000042433 | SmartIR Limited | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000040593 | Social Tech Projects ApS | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000036789 | SoHHytec SA | CH-Switzerland | Company | No | Alumnus | ESA BIC Switzerland | |
| 1000039053 | Soil Benchmark Ltd | GB-United Kingdom | Company | No | Alumnus | ESA BIC UK | |
| 1000040983 | Soilspect B.V. | NL-Netherlands | Company | Yes | Alumnus | ESA BIC Noordwijk | |
| 1000039520 | Solar Foods | FI-Finland | Company | Yes | Alumnus | ESA BIC Finland | |
| 1000036328 | Solenix Engineering GmbH | DE-Germany | Company | Yes | Alumnus | ESA BIC Hessen | |
| 1000045953 | SOLIDKOSMOS S.A. | GR-Greece | Company | Yes | Incubatee | ESA BIC Greece | |
| 1000041650 | Solmeyea | GR-Greece | Company | Yes | Alumnus | ESA BIC Greece | |
| 1000043716 | SolPure | AT-Austria | Company | No | Incubatee | ESA BIC Austria | |
| 1000044670 | Solsign Limited | IE-Ireland | Company | No | Incubatee | ESA BIC Ireland | |
| 1000038783 | Sorair Technologies LTD | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000043268 | Space 11 srl | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000025510 | Space Apps Kft. | HU-Hungary | Company | Yes | Alumnus | ESA BIC Hungary | |
| 1000027974 | Space Composite Structures DENMARK | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000039942 | SPACE DIMENSIONALLY OPTIMIZED TECHNOLOGY SATELLITES LTD - Space DOTS Ltd | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000034431 | Space For Life srl | IT-Italy | Company | Yes | Alumnus | ESA BIC Lazio | |
| 1000041457 | Space Innovation Solutions | GR-Greece | Company | Yes | Alumnus | ESA BIC Greece | |
| 1000031832 | Space Layer Technologies | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |