| 1000042724 | StellarShip Labs UG (haftungsbeschränkt) | DE-Germany | Company | Yes | Incubatee | ESA BIC Bavaria | |
| 1000039812 | StepUp Horse ApS | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000033433 | Sternula A/S | DK-Denmark | Company | Yes | Alumnus | ESA BIC Denmark | |
| 1000026904 | STRA, S.A. | PT-Portugal | Company | No | Alumnus | ESA BIC Portugal | |
| 1000038040 | STRADOT S.A.S. | FR-France | Company | No | Alumnus | ESA BIC Sud France | |
| 1000031500 | Strain 2 Data bvba | BE-Belgium | Company | No | Alumnus | ESA BIC Belgium | |
| 1000033385 | Stratobotic s.r.l. | IT-Italy | Company | Yes | Alumnus | ESA BIC Turin | |
| 1000033762 | STRATOSYST s.r.o. | CZ-Czech Republic | Company | Yes | Alumnus | ESA BIC Czech Republic | |
| 1000041505 | STRONGBÓ AGRITECH LIMITED | IE-Ireland | Company | No | Alumnus | ESA BIC Ireland | |
| 1000026720 | Studiomapp srl | IT-Italy | Company | No | Alumnus | ESA BIC Lazio | |
| 1000032462 | Styx Neutronica GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Baden-Württemberg | |
| 1000042128 | SunCubes Srl | IT-Italy | Company | No | Alumnus | ESA BIC Turin | |
| 1000039852 | SUNNYB Innovations GmbH | AT-Austria | Company | Yes | Alumnus | ESA BIC Austria | |
| 1000040613 | SunPlower Propeller GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Bavaria | |
| 1000041474 | SUNWELL | CH-Switzerland | Company | No | Alumnus | ESA BIC Switzerland | |
| 1000042909 | Supercluster Sp. z o.o. | PL-Poland | Company | No | Incubatee | ESA BIC Poland | |
| 1000037618 | super-sharp Space Systems Limited | GB-United Kingdom | Company | Yes | Alumnus | ESA BIC UK | |
| 1000033383 | SuperVision Earth GmbH | DE-Germany | Company | No | Alumnus | ESA BIC Hessen | |
| 1000042274 | Surplusmap AS | NO-Norway | Company | No | Alumnus | ESA BIC Norway | |
| 1000026758 | Survey Lab | IT-Italy | Company | Yes | Alumnus | ESA BIC Lazio | |